Here are the best goals from week #1 October 2010, courtesy of TVGOLO.com.
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| Goal#1 | Shannon Cole (Sydney FC) | vs North Queensland Fury |
| Goal#2 | Danielson (Nacional) | vs Sporting Lisbon |
| Goal#3 | Ismaïl Aissati (Vitesse Arnhem) | vs Excelsior Rotterdam |
| Goal#4 | Alex Sandro (Santos) | vs Cruzeiro |
| Goal#5 | Marc Richards (Port Vale) | vs Accrington Stanley |
| Goal#6 | Ádám Szalai (Mainz) | vs Bayern Munich |
| Goal#7 | Michael Brown (Portsmouth) | vs Leicester City |
| Goal#8 | Marcos Rojo (Estudiantes La Plata) | vs Boca Juniors |
| Goal#9 | Carlos Saleiro (Sporting Lisbon) | vs Nacional |
| Goal#10 | Milan Baroš (Galatasaray) | vs İstanbul BB |
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