Here are the best goals from week #5 October 2010, courtesy of TVGOLO.com.
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| Goal#1 | Mounir El Hamdaoui (Ajax Amsterdam) | vs Heereneveen |
| Goal#2 | Iago Aspas (Celta Vigo) | vs Granada |
| Goal#3 | Ezequiel Lavezzi (Napoli) | vs AC Milan |
| Goal#4 | Leighton Baines (Everton) | vs Tottenham Hotspur |
| Goal#5 | Charles (Córdoba) | vs Tenerife |
| Goal#6 | Koen van der Biezen (Go Ahead Eagles) | vs MVV Maastricht |
| Goal#7 | Lewis McGugan (Nottingham Forest) | vs Ipswich Town |
| Goal#8 | Hulk (FC Porto) | vs União Leiria |
| Goal#9 | Richard Ortiz (Club Olimpia) | vs Club Libertad |
| Goal#10 | Javier Hernández (Manchester United) | vs Stoke City |
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